Weight Loss Peptides — Ranked by Receptor Tier
Four receptor-agonist tiers, four generations of weight-loss pharmacology. Each tier shows its peak Phase-3 trial data alongside every vial size available in the catalog.
GLP-1 + GIP + Glucagon
−28.7% body weight
TRIUMPH-4 Phase 3 (Dec 2025)
GLP-1 + GIP receptors
−22.5% body weight
SURMOUNT-1 Phase 3 (NEJM 2022)
GLP-1 only (first-generation)
−14.9% body weight
STEP-1 Phase 3 (NEJM 2021)
Amylin receptor + GLP blends
−15.6% (CagriSema Phase 3)
Amylin + GLP-1 research pairing
Tier 01 · GLP-1 + GIP + Glucagon
Triple Agonist
Peak trial data
−28.7% body weight
Retatrutide 10mg
Buy Retatrutide 10mg online — research-grade lyophilized peptide for laboratory use. Triple GLP-1/GIP/Glucagon receptor agonist. ≥98% HPLC purity verified.
CAS: 2381089-83-2
Retatrutide 15mg
Buy Retatrutide 15mg online — research-grade lyophilized peptide for laboratory use. Triple GLP-1/GIP/Glucagon receptor agonist. ≥98% HPLC purity verified.
CAS: 2381089-83-2
Tier 02 · GLP-1 + GIP receptors
Dual Agonist
Peak trial data
−22.5% body weight
Tirzepatide 15mg
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CAS: 2023788-19-2
Mazdutide 6mg
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CAS: 2259320-21-7
Tier 03 · GLP-1 only (first-generation)
Mono GLP-1 Agonist
Peak trial data
−14.9% body weight
Semaglutide 12mg
Buy Semaglutide 12mg online — research-grade lyophilized peptide for laboratory use. GLP-1 receptor agonist (31-amino acid lipidated peptide). ≥98% HPLC purity verified.
CAS: 910463-68-2
Semaglutide 20mg
Buy Semaglutide 20mg online — research-grade lyophilized peptide for laboratory use. GLP-1 receptor agonist (31-amino acid lipidated peptide). ≥98% HPLC purity verified.
CAS: 910463-68-2
Semaglutide 30mg
Buy Semaglutide 30mg online — research-grade lyophilized peptide for laboratory use. GLP-1 receptor agonist (31-amino acid lipidated peptide). ≥98% HPLC purity verified.
CAS: 910463-68-2
Tier 04 · Amylin receptor + GLP blends
Amylin / Co-Agonist
Peak trial data
−15.6% (CagriSema Phase 3)
Cagri-Reta 10mg
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Cagri-Reta 5mg
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Cagri-Sema Blend 10mg
Buy Cagri-Sema Blend 10mg online — research-grade lyophilized peptide for laboratory use. Long-acting amylin analog. ≥98% HPLC purity verified.
CAS: 1415456-99-3
Tier 05 · AMPK, β-oxidation, adipocyte pathways
Non-GLP Metabolic
Peak trial data
Varies by compound
5-Amino-1MQ 50mg
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CAS: 104819-09-2
5-Amino-1MQ 5mg
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CAS: 104819-09-2
AOD9604 10mg
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CAS: 221231-10-3
GLP-Class Research FAQ
What is the most potent weight-loss research peptide available?
Retatrutide, a triple agonist (GLP-1 + GIP + Glucagon), has the highest published weight-loss data — −28.7% at 72 weeks in the TRIUMPH-4 Phase 3 trial. It exceeds every single or dual agonist tested to date in head-to-head comparisons.
How does Tirzepatide compare to Semaglutide in trials?
Head-to-head (SURMOUNT-5, 2025): Tirzepatide 15mg achieved −20.2% body weight vs −13.7% for Semaglutide 2.4mg at 72 weeks — approximately 47% greater weight loss on the dual-agonist mechanism.
What are Cagrilintide and the CagriSema blend?
Cagrilintide is a long-acting amylin analog. CagriSema (Cagrilintide + Semaglutide) combines amylin-mediated satiety with GLP-1 agonism. Phase 3 trials showed superior efficacy to semaglutide alone.
Are research peptides like Retatrutide FDA-approved?
As of 2026, Retatrutide is in Phase 3 trials and not FDA-approved. Tirzepatide is FDA-approved for obesity (Zepbound). Semaglutide is FDA-approved for obesity (Wegovy) and diabetes (Ozempic). All research-grade supply is for laboratory use only.