Muscle Growth Peptides — Mapped to the Axis
The GH axis cascades from hypothalamus → pituitary → liver. Each compound class engages a specific point in that chain. Pairing compounds from different nodes produces the classic pulsatile-amplification stacking pattern documented in Teichman 2006.
Axis cascade
Node 1
Hypothalamus
GHRH release → primary signal to pituitary
Node 2
Pituitary
GH pulse amplifier via ghrelin-receptor engagement
Node 3
Synergistic Blends
Dual-receptor engagement — GHRH + GHRP combined
Node 4
Downstream IGF-1
Direct IGF-1R activation + sustained plasma elevation
Axis node 1 · GHRH analogs
Hypothalamus
GHRH release → primary signal to pituitary
CJC-1295 No DAC 10mg
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CJC-1295 No DAC 5mg
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CJC-1295 with DAC 10mg
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Sermorelin 10mg
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Sermorelin 2mg
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Sermorelin 5mg
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Axis node 2 · GHRP secretagogues
Pituitary
GH pulse amplifier via ghrelin-receptor engagement
Ipamorelin 10mg
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GHRP-2 10mg
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Axis node 3 · Blended secretagogues
Synergistic Blends
Dual-receptor engagement — GHRH + GHRP combined
Ipamorelin/CJC-1295 Blend 10mg
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Axis node 4 · IGF-1 analogs / carriers
Downstream IGF-1
Direct IGF-1R activation + sustained plasma elevation
Key research note
GHRH + GHRP stacking produces 2–10x GH amplification
Teichman et al. (2006) demonstrated that co-administered GHRH analogs (like CJC-1295) and GHRP secretagogues (like Ipamorelin) activate two distinct receptor systems with additive effects on pituitary GH output. This is why the CJC-1295 + Ipamorelin pairing has become the most-researched stack in the GH axis peptide literature.
Growth-Axis Research Q&A
Why stack CJC-1295 with Ipamorelin?
CJC-1295 engages GHRH receptors while Ipamorelin engages ghrelin receptors (GHSR-1a) — two distinct pathways that both trigger pituitary GH release. Combined, they produce a 2–10x GH amplification with no overlap in receptor binding.
What is the difference between CJC-1295 DAC and No-DAC?
DAC (Drug Affinity Complex) extends CJC-1295's plasma half-life from ~30 minutes to 6–8 days, enabling once-weekly dosing with sustained IGF-1 elevation. No-DAC requires daily/nightly administration and is preferred for research protocols targeting the natural pulsatile pattern.
Is IGF-1 LR3 the same as native IGF-1?
LR3 refers to a Long Arg3 modification — the 3rd amino acid is replaced with arginine and a 13-AA N-terminal extension is added. This modification extends the half-life from minutes (native) to 20–30 hours and reduces binding-protein interaction for higher free-IGF-1 availability.
Does Tesamorelin differ from CJC-1295?
Tesamorelin is an FDA-approved GHRH analog (Egrifta, for HIV-associated lipodystrophy). CJC-1295 is a research-only GHRH analog. Both engage GHRH receptors, but Tesamorelin has an established clinical pharmacokinetic profile while CJC-1295 is optimized for research protocols.