Telomere & Telomerase Research
Research on epithalon's role in telomerase activation and telomere length maintenance.
Telomere & Telomerase Research
Epithalon (Ala-Glu-Asp-Gly, CAS: 307297-39-8) is a synthetic tetrapeptide based on epithalamin — a natural extract from the bovine pineal gland. Dr. Vladimir Khavinson's research at the St. Petersburg Institute of Bioregulation demonstrated epithalon's ability to activate telomerase.
Telomere Biology
Telomeres are repetitive DNA sequences (TTAGGG) that cap chromosome ends, protecting genetic material from degradation. Each cell division shortens telomeres slightly. When telomeres become critically short, cells enter senescence or apoptosis — a hallmark of biological aging.
Telomerase Mechanism
Telomerase is a ribonucleoprotein enzyme that adds telomeric repeats to chromosome ends. Most somatic cells have low or absent telomerase activity, while germ cells, stem cells, and cancer cells maintain high activity.
Khavinson's key findings:
- Epithalon increased telomerase activity in human fetal fibroblasts in vitro
- Treated cells showed extended replicative capacity vs controls
- Telomere length was maintained over additional population doublings
- No malignant transformation was observed in treated cells
Implications for Aging Research
Telomere shortening is considered a primary biomarker of cellular aging. Epithalon's telomerase-activating properties position it as a research tool for studying cellular senescence, replicative capacity, and potential anti-aging interventions.
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Telomere & Telomerase Research — Available Products
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Epithalon 50mg
A synthetic tetrapeptide (Ala-Glu-Asp-Gly) derived from the natural pineal peptide epithalamin. The most studied peptide bioregulator — 40+ years of research covering telomerase activation, telomere elongation, anti-aging, melatonin regulation, and lifespan extension in rodent models. Supplied as lyophilized powder for laboratory research.
CAS: 307297-39-8
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Frequently Asked Questions
How does epithalon activate telomerase?
Epithalon stimulates telomerase gene expression, increasing activity of the enzyme that adds telomeric repeats to chromosome ends. This may extend cellular replicative capacity by maintaining telomere length.
What is the Khavinson research?
Dr. Vladimir Khavinson at the St. Petersburg Institute conducted decades of research on pineal peptides including epithalon, showing telomerase activation in human fibroblasts and extended cellular lifespan without malignant transformation.
Does epithalon prevent aging?
Epithalon is a research compound studied for cellular mechanisms related to aging. Research shows telomerase activation and extended replicative capacity in cell models; human aging research is ongoing.
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