Research Specifications
- Sequence:
- Ac-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-NH2 (Ac-EEMQRRADE-NH2)
- INCI Name:
- Acetyl Glutamyl Heptapeptide-3
- CAS Number:
- 868844-74-0
- Molecular Weight:
- 1075.2 Da
- Form:
- Lyophilized powder
- Purity:
- ≥98% (HPLC verified)
- Storage:
- −20°C long-term / 4°C up to 4 weeks
SNAP-8
Acetyl Octapeptide-3 — an 8-amino acid SNARE complex mimic studied for expression wrinkle reduction via neuromuscular junction modulation.
SNARE Complex Inhibition at the Neuromuscular Junction
SNAP-8 (Acetyl Glutamyl Heptapeptide-3, CAS: 868844-74-0) is a synthetic octapeptide (Ac-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-NH2) that mimics the N-terminal end of SNAP-25, a key protein in the SNARE (Soluble NSF Attachment Protein REceptor) complex responsible for synaptic vesicle docking and neurotransmitter release. At the neuromuscular junction, SNARE complex assembly drives acetylcholine vesicle fusion — initiating muscle contraction. SNAP-8 competes with native SNAP-25 for SNARE complex formation, modulating the release of catecholamines from nerve endings. Reduced neurotransmitter release → reduced muscle contraction frequency → reduced mechanical stress on overlying dermis from repetitive facial expressions. Studies at 10% concentration in topical formulations have shown measurable reduction in forehead wrinkle depth as assessed by optical profilometry after 4–28 days of twice-daily application. Molecular weight: 1075.2 Da.
Research Highlights
SNARE Complex Modulation
SNAP-8 targets the SNARE complex — the molecular machinery that drives synaptic vesicle fusion and neurotransmitter release. By competing with native SNAP-25 for complex assembly, it modulates acetylcholine release at the neuromuscular junction without blocking it entirely, preserving normal muscle function while reducing high-frequency contraction patterns.
Expression Line Research
The primary research application for SNAP-8 is expression wrinkle formation. Repetitive facial muscle contractions — squinting, frowning, smiling — create mechanical stress on the dermis that forms expression lines over time. SNAP-8 models investigate whether reducing contraction frequency via NMJ modulation can reduce this mechanical stress.
Topical Formulation Studies
Unlike most research peptides which are administered parenterally, SNAP-8 has been studied in topical delivery models. Small molecular weight (1075 Da) and amphiphilic character support skin penetration studies. Research has investigated encapsulation in liposomal and nanoparticle carriers for enhanced dermal delivery.
Research FAQ
What is SNAP-8?
How does SNAP-8 differ from Botulinum toxin?
What concentration is used in SNAP-8 research?
Research Use Only. This product is intended for in-vitro laboratory research only. Not for human consumption, injection, or therapeutic use. Not medical advice. Always consult applicable regulations in your jurisdiction.
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SNAP-8
$45.00